When you want to modify a Windows Vista System File and it says that the file is denied or saving the file is denied or make sure the file name and path are correct.
This issue occurs even though you log on by using an account that has administrative credentials.
WORKAROUND
To work around this issue, follow these steps:
1. Click Start, click All Programs, click Accessories, right-click Notepad, and then click Run as administrator.
If you are prompted for an administrator password or for a confirmation, type the password, or click Allow.
2. Open your file in Notepad, make the necessary changes, and then click Save on the Edit menu.